These elementary steps can be classified in a few major classes: addition, elimination, substitution, and pericyclic reactions. It uses chemical kinetics, spectroscopy, isotope effects, and quantum chemistry to determine the sequence of elementary steps involved in a reaction. The study of reactivity focuses on the mechanisms of organic reactions. Finally, the acid-base chemistry of the molecules is studied in terms of structure, based on resonance and inductive effects and through the use of linear free-energy relations. Supramolecular structure is also considered in terms of intermolecular forces including hydrogen bonding. Other topics in structure include stereochemistry and conformational analysis. The study of structure starts from chemical bonding, with special emphasis on the stability of organic molecules due to factors such as steric strain and aromaticity. The two main themes in physical organic chemistry are structure and reactivity.
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